Publications
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Publications on Hematopoietic Stem cell derived NK cells and inaleucel (oNKord)

Qualification of a flow cytometry-based method for the evaluation of in vitro cytotoxicity of GTA002 natural killer cell therapy

Raimo M. et al

Heliyon, 2024 (R&D)

Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer

Toffoli E.C. et al

J Immunother Cancer, 2023 (Research)

Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells

Van Vliet AA et al

 iScience, 2023 (Research and in vitro preclinical)

Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells

Douka S. et al

J Control Release, 2023, Research

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Lamers-Kok N et al

J Hematol Oncol., 2022 (Clinical NK landscape, review) 

Boosting Natural Killer Cell Therapies in Glioblastoma Multiforme Using Supramolecular Cationic Inhibitors of Heat Shock Protein 90

Saha T et al

Front Mol Biosci., 2021 (Combination therapies)

Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor

Toffoli EC et al

Cancers (Basel). 2021 (Combination therapies)

Adoptive NK Cell Therapy: A Promising Treatment Prospect for Metastatic Melanoma

van Vliet AA, G et al

Cancers (Basel). 2021 (Melanoma & NK field review)

Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response

Toffoli EC et al

Cancers (Basel). 2021 (NK field review)

Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function

Mantesso S et al

Front Immunol. 2020 (Genetically modified NK field review)

Successful Transfer of Umbilical Cord Blood CD34+ Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients

Dolstra H et al

Clin Cancer Res. 2017 (Phase I clinical trial - fresh cells)

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

Veluchamy JP et al

Front Immunol. 2017 (NK field review)

The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development

Post M et al

Front Immunol. 2017 (Research and Discovery) 

In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer

Veluchamy JP et al

Front Immunol. 2017 (Research, Combination therapies and Pre-clinical) 

High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

Veluchamy JP et al

Cancer Immunol Immunother. 2017 (Research and Pre-clinical) 

Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer

Cany J et al

Oncoimmunology. 2015 (Research and Discovery)

Improving the outcome of leukemia by natural killer cell-based immunotherapeutic strategies

Chouaib S et al

Front Immunol. 2014 (Leukemia - NK field review) 

IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential

Lehmann D et al

PLoS One. 2014 (Research and Discovery) 

Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice

Cany J et al

PLoS One. 2013 (Research and Pre-clinical) 

Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells

Lehmann D et al

Cells Dev. 201 Stem 2 (Research and Discovery)

Natural killer cell differentiation from hematopoietic stem cells: a comparative analysis of heparin- and stromal cell-supported methods

Dezell SA et al

Biol Blood Marrow Transplant. 2012. (Research and Discovery)

Clinical-grade generation of active NK cells from cord blood hematopoietic progenitor cells for immunotherapy using a closed-system culture process

Spanholtz J et al

PLoS One. 2011 (Discovery and technology development)

High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy

Spanholtz J et al

PLoS One. 2010 (Discovery and technology development)